Open AccessDeoxycholic Acid and Lithocholic Acid Alleviate Liver Injury and Inflammation in Mice with Klebsiella pneumoniae-Induced Liver Abscess and Bacteremia
Author(s) -
Yu Zheng,
Chengcheng Yue,
Hui Zhang,
Haoran Chen,
Yanyan Liu,
Jiabin Li
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s298495
Subject(s) - lithocholic acid , bile acid , klebsiella pneumoniae , deoxycholic acid , microbiology and biotechnology , biology , liver injury , small intestinal bacterial overgrowth , inflammation , immunology , medicine , pharmacology , endocrinology , biochemistry , escherichia coli , gene , irritable bowel syndrome
Klebsiella pneumoniae -induced liver abscess and baiacterem is a serious infectious disease with high mortality. Secondary bile acids (SBAs) are produced by intestinal flora through the metabolism of primary bile acids and play a role in promoting or inhibiting inflammation in some diseases. However, the immunomodulatory role of SBAs in bacterial infections of the liver remains unclear. This study aimed to investigate the anti-inflammatory and liver-protective effects of SBAs in K. pneumoniae- infected mice.