Open AccessEngeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo
Author(s) -
Hao Wang,
Zengxin Jiang,
Zhiying Pang,
Guobin Qi,
Bingxuan Hua,
Zuoqin Yan,
Yuan Hou
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s297166
Subject(s) - aggrecan , chondrocyte , mmp3 , chemistry , reactive oxygen species , apoptosis , microbiology and biotechnology , cartilage , mmp9 , blot , matrix metalloproteinase , downregulation and upregulation , biochemistry , osteoarthritis , biology , medicine , pathology , gene expression , in vitro , anatomy , alternative medicine , gene , articular cartilage
Osteoarthritis (OA) is a progressive disease characterized by pain and impaired joint functions. Engeletin is a natural compound with anti-inflammatory and antioxidant effects on other diseases, but the effect of engeletin on OA has not been evaluated. This study aimed to elucidate the protective effect of engeletin on cartilage and the underlying mechanisms.