Open AccessKCa3.1 Inhibition of Macrophages Suppresses Inflammatory Response Leading to Endothelial Damage in a Cell Model of Kawasaki Disease
Author(s) -
Fei Zheng,
Yijing Tao,
Jingjing Liu,
Zhimin Geng,
Ying Wang,
Yujia Wang,
Songling Fu,
Wei Wang,
Chunhong Xie,
Yiying Zhang,
Fangqi Gong
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s297131
Subject(s) - inflammation , signal transduction , western blot , chemistry , macrophage , endothelial stem cell , stat3 , microbiology and biotechnology , nf κb , in vitro , immunology , biology , biochemistry , gene
Macrophages-mediated inflammation is linked with endothelial damage of Kawasaki disease (KD). KCa3.1, a calcium-activated potassium channel, modulates inflammation of macrophages. However, little is known about the role of KCa3.1 in inflammation by macrophages involved in KD. Hence, this study is aimed to explore the potential role of KCa3.1 in regulating inflammatory response by macrophages and subsequent vascular injury in an in vitro model of KD.