Open AccessHigh Concentrations of Etanercept Reduce Human Islet Function and Integrity
Author(s) -
Daniel Brandhorst,
Heide Brandhorst,
Samuel Acreman,
Anju Abraham,
Paul Johnson
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s294663
Subject(s) - islet , etanercept , hypoxia (environmental) , medicine , pharmacology , endocrinology , tumor necrosis factor alpha , andrology , diabetes mellitus , chemistry , oxygen , organic chemistry
Most islet transplant groups worldwide routinely use the TNFα inhibitor Etanercept in their peri-transplant protocols. Surprisingly, there have been no published dose-response studies on the effects of Etanercept on human islets. Our study aimed to address this by treating cultured human islets with increasing concentrations of Etanercept.