Open AccessAltered Monocyte Subsets in Kawasaki Disease Revealed by Single-cell RNA-Sequencing
Author(s) -
Zhimin Geng,
Yijing Tao,
Fei Zheng,
Linlin Wu,
Ying Wang,
Yujia Wang,
Yameng Sun,
Songling Fu,
Wei Wang,
Chunhong Xie,
Yiying Zhang,
Fangqi Gong
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s293993
Subject(s) - cd14 , cd16 , monocyte , immunology , immune system , biology , flow cytometry , innate immune system , kawasaki disease , transcriptome , medicine , gene , genetics , cd3 , cd8 , gene expression , artery
Kawasaki disease (KD) is characterized by a disorder of immune response, and its etiology remains unknown. Monocyte is an important member of the body's innate immune system; however its role in KD is still elusive due to its ambiguous heterogeneity and complex functions. We aim to comprehensively delineate monocyte heterogeneity in healthy and KD infants and to reveal the underlying mechanism for KD.