Open AccessDexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling
Author(s) -
Yang Yu,
Hui Wang,
Nan Song,
Youen Jiang,
Jun Zhang,
Xiao Wen Meng,
Xiao Feng,
Hong Liu,
Ke Peng,
Fu Ji
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s292263
Subject(s) - dexmedetomidine , cardioprotection , reperfusion injury , medicine , pharmacology , endoplasmic reticulum , inflammation , ischemia , apoptosis , endocrinology , chemistry , biochemistry , sedation
Endoplasmic reticulum stress (ERS)-mediated myocardial inflammation and apoptosis plays an important role in myocardial ischemia/reperfusion (I/R) injury. Dexmedetomidine has been used clinically with sedative, analgesic, and anti-inflammatory properties. This study aimed to determine the effects of dexmedetomidine pretreatment on inflammation, apoptosis, and the expression of ERS signaling during myocardial I/R injury.