Open AccessMechanisms of Adiponectin in Regulation of Proinflammatory Cytokine Production and Migration in Macrophages
Author(s) -
Xiaofei Jin,
Yanlin Wang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s292137
Subject(s) - proinflammatory cytokine , adiponectin , cytokine , immunology , production (economics) , macrophage , inflammation , medicine , biology , economics , biochemistry , insulin resistance , in vitro , insulin , macroeconomics
Evidence indicate that adiponectin may exert pro-inflammatory effects on inflammatory cells. We have found that adiponectin knockout decreased inflammatory reaction and tubular damage in the ischemia-reperfusion kidney in APN-knockout mice. Globular adiponectin and full-length adiponectin (g-APN and f-APN) were used in this study to investigate the effects of adiponectin on proinflammatory cytokines production and migration in Raw 264.7 cells.