Open AccessRole of Pyroptosis in Diabetes and Its Therapeutic Implications
Author(s) -
Abdullah Al Mamun,
Yanqing Wu,
Fatema Nasrin,
Afroza Akter,
Masuma Afrin Taniya,
Fahad Munir,
Chang Jia,
Jian Xiao
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s291453
Subject(s) - pyroptosis , inflammasome , caspase 1 , inflammation , programmed cell death , diabetes mellitus , proinflammatory cytokine , medicine , interleukin , microbiology and biotechnology , apoptosis , immunology , chemistry , biology , cytokine , biochemistry , endocrinology
Pyroptosis is mainly considered as a new pro-inflammatory mediated-programmed cell death. In addition, pyroptosis is described by gasdermin-induced pore formation on the membrane, cell swelling and rapid lysis, and several pro-inflammatory mediators interleukin-1β (IL-1β) and interleukin-18 (IL-18) release. Extensive studies have shown that pyroptosis is commonly involved by activating the caspase-1-dependent canonical pathway and caspase-4/5/11-dependent non-canonical pathway. However, pyroptosis facilitates local inflammation and inflammatory responses. Current researches have reported that pyroptosis promotes the progression of several diabetic complications. Emerging studies have suggested that some potential molecules targeting the pyroptosis and inflammasome signaling pathways could be a novel therapeutic avenue for managing and treating diabetes and its complications in the near future. Our narrative review concisely describes the possible mechanism of pyroptosis and its progressive understanding of the development of diabetic complications.