Open AccessEfficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema
Author(s) -
Kuluvar Gouthamchandra,
Heggar Venkataramana Sudeep,
S. Chandrappa,
Amrith Raj,
Puttaswamy Naveen,
Kodimule Shyamaprasad
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s291293
Subject(s) - nitric oxide synthase , nitric oxide , pharmacology , chemistry , curcumin , carrageenan , inflammation , tumor necrosis factor alpha , xanthine oxidase , cyclooxygenase , curcuminoid , proinflammatory cytokine , biochemistry , immunology , medicine , enzyme , organic chemistry
It is well known that regular turmeric extract with 95% curcuminoid is comprised of curcumin (70.07%), desmethoxycurcumin (20.28%), and bisdemethoxycurcumin (BDMC) (3.63%). In the current study for the first time, we have enriched about 3% of bisdemethoxycurcumin (BDMC) to 70% as well as named it as REVERC3 and compared anti-inflammatory activity with regular turmeric extract using in vitro and in vivo models of inflammation.