Open AccessYAP Deficiency Attenuates Pulmonary Injury Following Mechanical Ventilation Through the Regulation of M1/M2 Macrophage Polarization
Author(s) -
Qi Luo,
Jing Luo,
Yanlin Wang
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s288244
Subject(s) - macrophage polarization , tumor necrosis factor alpha , inflammation , proinflammatory cytokine , m2 macrophage , alveolar macrophage , macrophage , immunology , lung , medicine , microbiology and biotechnology , biology , in vitro , biochemistry
Evidences indicate that the balance between macrophage M1 and M2 polarization is essential for the regulation of pulmonary inflammation during mechanical ventilation (MV). Yes-associated protein (YAP) is a key component of the Hippo pathway and was suggested to regulate macrophage polarization. This study was designed to investigate whether YAP contributes to pulmonary inflammation during MV.