Open AccessInhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival
Author(s) -
Ao Ren,
Zhongqiu Li,
Xuzhi Zhang,
Ronghai Deng,
Yi Ma
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s287453
Subject(s) - biology , islet , immune system , dendritic cell , immune tolerance , transplantation , immunology , microbiology and biotechnology , spleen , viral vector , cancer research , recombinant dna , medicine , endocrinology , gene , insulin , biochemistry
The ability of dendritic cells (DCs) to initiate an immune response or induce immune tolerance depends on their maturation status. Dendritic-cell-associated C-type lectin 1 (Dectin-1) plays a key role in the differentiation, activation, and maturation of DCs. Therefore, we hypothesized that inhibition of Dectin-1 could prevent DC maturation and induce immune tolerance of transplanted organs.