Open Access<p>MicroRNA-21 Mediates a Positive Feedback on Angiotensin II-Induced Myofibroblast Transformation</p>
Author(s) -
Dongjiu Li,
Chengyu Mao,
Enbo Zhou,
Jiayin You,
Erhe Gao,
Zhihua Han,
Yuqi Fan,
Qing He,
Changqian Wang
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s285714
Subject(s) - angiotensin ii , myofibroblast , gene knockdown , fibrosis , cardiac fibrosis , medicine , microrna , cancer research , pathogenesis , transforming growth factor , endocrinology , knockout mouse , chemistry , receptor , apoptosis , gene , biochemistry
Post myocardial infarction (MI) fibrosis has been identified as an important factor in the progression of heart failure. Previous studies have revealed that microRNA-21 (miR-21) plays an important role in the pathogenesis of fibrosis. The purpose of this study was to explore the role of miR-21 in post-MI cardiac fibrosis.