Open AccessElectroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity
Author(s) -
Yan Chen,
Jidong Cheng,
Yiling Zhang,
Jiande D.Z. Chen,
Florin M Seralu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s285146
Subject(s) - medicine , trpv1 , tropomyosin receptor kinase a , nerve growth factor , electroacupuncture , tryptase , endocrinology , mast cell , pathology , anesthesia , immunology , acupuncture , transient receptor potential channel , receptor , alternative medicine
The aim of the study was to investigate the effects of electroacupuncture (EA) at ST36 on rectal hypersensitivity and compliance in DSS-treated post-inflammation rats. In addition, we explored the involvement of mast cells-triggered NGF/TrkA/TRPV1 peripheral afferent pathway.