Open Access<p>Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments</p>
Author(s) -
Peipei Cao,
Hao Zhang,
Huiling Meng,
Yajia Cheng,
Haiqi Xu,
Siwen Zang,
Zongjin Li,
Jianlin Cui,
Yuhao Li
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s282128
Subject(s) - celecoxib , remyelination , microglia , myelin , zebrafish , neuroprotection , western blot , neuroinflammation , pharmacology , chemistry , cancer research , myelin basic protein , downregulation and upregulation , apoptosis , inflammation , biology , immunology , central nervous system , biochemistry , endocrinology , gene
The myelin sheath can be damaged by genetic and/or environmental factors, leading to demyelinating diseases, for which effective treatments are lacking. Recently, cyclooxygenase-2 (COX-2) overexpression was detected in demyelinating lesions both in patients and animal models, opening an avenue for promoting endogenous remyelination. The aim of this study was to investigate the therapeutic effect of celecoxib, a selective COX-2 inhibitor, against demyelination in a zebrafish model.