Open Access<p>Multiple Components Rapidly Screened from Perilla Leaves Attenuate Asthma Airway Inflammation by Synergistic Targeting on Syk</p>
Author(s) -
Hui Yang,
Wei Sun,
Pei Ma,
ChunSuo Yao,
Yannan Fan,
Shuyi Li,
Jing Yuan,
Ziqian Zhang,
Xuyu Li,
Mingbao Lin,
Qi Hou
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s281393
Subject(s) - syk , perilla frutescens , allergic inflammation , chemistry , asthma , in vitro , inflammation , pharmacology , perilla , immunoglobulin e , immunology , medicine , biochemistry , receptor , antibody , tyrosine kinase , raw material , organic chemistry
Perilla frutescens (L.) Britt., a classic medicinal plant, has been demonstrated to have anti-inflammatory and anti-allergic effects in asthma. Perilla leaves extract (PLE) exerted significant therapeutic effect against allergic asthma inflammation through Syk inhibition. But the active chemical ingredients from PLE are complex and unclear, it is difficult to fully elucidate its pharmacological mechanisms.