Open Access<p>Sinapic Acid Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration</p>
Author(s) -
Jinfeng Huang,
Xuan-Qi Zheng,
Jialiang Lin,
Kai Zhang,
Haijun Tian,
Wenxian Zhou,
Hui Wang,
Ze Gao,
Haiming Jin,
Ai-Min Wu
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s278556
Subject(s) - chemistry , nitric oxide synthase , tunel assay , apoptosis , nitric oxide , intervertebral disc , aggrecan , prostaglandin e2 , interleukin , tumor necrosis factor alpha , nucleus , microbiology and biotechnology , cytokine , pathology , medicine , endocrinology , biochemistry , biology , anatomy , osteoarthritis , alternative medicine , articular cartilage , organic chemistry
Low back pain (LBP) is a very common condition and leads to serious pain, disability, and price tag all over the world. Intervertebral disk degeneration (IDD) is one of the major reasons that contributed to LBP. The levels of interleukin 1 beta (IL-1β) increase significantly in degenerative disks. IL-1β also accelerates IDD. Sinapic acid (SA) has the effect of anti-inflammatory, antioxidant and antimicrobial. However, the effect of SA on IDD has never been studied. Therefore, the aim of this study was to figure out whether SA has protective effect on nucleus pulposus (NP) cells and further explore the possible underlying mechanism.