Open Access<p>Pathogen-Associated Molecules from Gut Translocation Enhance Severity of Cecal Ligation and Puncture Sepsis in Iron-Overload β-Thalassemia Mice</p>
Author(s) -
Kritsanawan Sae-khow,
Awirut Charoensappakit,
Peerapat Visitchanakun,
Wilasinee Saisorn,
Saovaros Svasti,
Suthat Fucharoen,
Asada Leelahavanichkul
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s273329
Subject(s) - sepsis , pathogen , thalassemia , chromosomal translocation , medicine , bacterial translocation , ligation , immunology , microbiology and biotechnology , gastroenterology , biology , gene , genetics
Systemic inflammation induced by gut translocation of lipopolysaccharide (LPS), a major component of Gram-negative bacteria, in thalassemia with iron-overload worsens sepsis. However, the impact of (1→3)-β-D-glucan (BG), a major fungal molecule, in iron-overload thalassemia is still unclear. Hence, the influence of BG was explored in 1) iron-overload mice with sepsis induced by cecal ligation and puncture (CLP) surgery; and 2) in bone marrow-derived macrophages (BMMs).