Open Access<p>Active <em>Cousinia thomsonii</em> Extracts Modulate Expression of Crucial Proinflammatory Mediators/Cytokines and NFκB Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model</p>
Author(s) -
Khalid Bashir Dar,
Ishfaq Khan,
Shajrul Amin,
Aijaz Hassan Ganie,
Aashiq Hussain Bhat,
Showkat Ahmad Dar,
Bilal Ahmad Reshi,
Showkat Ahmad Ganie
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s272539
Subject(s) - proinflammatory cytokine , pharmacology , chemistry , anti inflammatory , lipopolysaccharide , inflammation , biochemistry , medicine , immunology
Chronic inflammation is implicated in a multitude of diseases, including arthritis, neurodegeneration, autoimmune myositis, type 2 diabetes, rheumatic disorders, spondylitis, and cancer. Therefore, strategies to explore potent anti-inflammatory regimens are pivotal from a human-health perspective. Medicinal plants represent a vast unexplored treasure trove of therapeutically active constituents with diverse pharmacological activities, including anti-inflammatory properties. Herein, we evaluated Cousinia thomsonii , an edible medicinal herb, for its anti-inflammatory/immunomodulatory properties.