Open Access<p>Overexpression of Aquaporin 1 in Synovium Aggravates Rat Collagen-Induced Arthritis Through Regulating β-Catenin Signaling: An in vivo and in vitro Study</p>
Author(s) -
Yu-rong Mu,
Meng-Yuan Zhou,
Li Cai,
Mingming Liu,
Rong Li
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s271664
Subject(s) - in vivo , in vitro , chemistry , arthritis , microbiology and biotechnology , catenin , collagen induced arthritis , signal transduction , cancer research , immunology , medicine , biology , wnt signaling pathway , biochemistry
Previous studies have confirmed that aquaporin 1 (AQP1) is up-regulated in synovium of rheumatoid arthritis (RA), but its exact pathogenic mechanisms in RA are unclear. This study revealed the pathogenic role of AQP1 in rat collagen-induced arthritis (CIA) and the underlying mechanisms related to β-catenin signaling.