Open Access<p>Immune-Mediated Necrotizing Myopathy Initially Presenting as Erythema Nodosum</p>
Author(s) -
Shilong Ying,
Sheng Li,
Sha Tang,
Qingguo Sun,
Deren Fang,
Yali Li,
Dexi Zhu,
Hong Fang,
Jianjun Qiao
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s270114
Subject(s) - erythema nodosum , medicine , myopathy , gastroenterology , disease
Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by severe diffuse proximal myofiber necrosis in the context of inflammatory myopathy. Autoantibodies of anti-signal recognition particle and anti-hydroxy-3-methylglutaryl-CoA reductase are two antibodies specific to IMNM. Erythema nodosum (EN) is often accompanied by various systemic diseases, such as autoimmune diseases. Herein, we report a female patient with signal recognition particle-associated IMNM, with EN as the first presentation. She showed significant clinical improvement after the initiation of glucocorticoids, intravenous immunoglobulin, rituximab, and mycophenolate mofetil. This case indicates that IMNM can initially present as EN. IMNM and EN might have overlapping pathogeneses.