Open Access<p>NLRP3 Regulated CXCL12 Expression in Acute Neutrophilic Lung Injury</p>
Author(s) -
Yanwen Peng,
Qiongli Wu,
Hao Tang,
Jingrou Chen,
Qili Wu,
Xiaofeng Yuan,
Shiqiu Xiong,
Yujin Ye,
Haijin Lv
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s259633
Subject(s) - chemokine , cxcl1 , lung , myeloperoxidase , lipopolysaccharide , medicine , immunology , inflammation , inflammasome
Both NLRP3 inflammasome and chemokines are involved in the initiation and development of acute lung inflammation, but the underlying mechanism is still elusive. The present study investigated the role of chemokines and NLRP3 in recruiting neutrophils in the early phase of acute lung injury.