Open Access<p>Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation</p>
Author(s) -
Sara Hemmati,
Mohammad Amin Sadeghi,
Hasan YousefiManesh,
Mostafa Eslamiyeh,
Ali Vafaei,
Laleh Foroutani,
Ghazaleh Donyadideh,
Ahmad Reza Dehpour,
Nima Rezaei
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s258991
Subject(s) - experimental autoimmune encephalomyelitis , microglia , multiple sclerosis , integrin alpha m , encephalomyelitis , medicine , spinal cord , downregulation and upregulation , pharmacology , intraperitoneal injection , immunology , astrogliosis , pathology , immune system , central nervous system , inflammation , chemistry , endocrinology , biochemistry , psychiatry , gene
Reactive oxygen and nitrogen species (ROS and RNS) are involved in pathologic mechanisms underlying demyelination and exacerbation in multiple sclerosis (MS) lesions. P47phox is the most important subunit of an ROS-producing enzyme (NADPH oxidase) which is reportedly upregulated in MS plaques due to the intense activity of infiltrated immune cells and resident microglia. Leukadherin1 is a specific CD11b/CD18 agonist that inhibits signaling and transmigration of inflammatory cells to sites of injury. Based on this mechanism, we evaluated therapeutic effects of leukadherin1 in an animal model of targeted experimental autoimmune encephalomyelitis (EAE) through focal injection of inflammatory cytokines to the spinal cord.