Open Access<p>IgGs-Abzymes from the Sera of Patients with Systemic Lupus Erythematosus Hydrolyzed miRNAs</p>
Author(s) -
Evgeny A. Ermakov,
Evelina M. Kabirova,
А. Э. Сизиков,
Valenti. Buneva,
Georgy A. Nevinsky
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s258558
Subject(s) - antibody , chemistry , microbiology and biotechnology , hydrolysis , immunology , microrna , sepharose , lupus erythematosus , biochemistry , medicine , biology , enzyme , gene
Systemic lupus erythematosus (SLE) is an inflammatory disease. The sera of SLE patients contain antibodies-abzymes hydrolyzing myelin basic protein (MBP), DNA, nucleotides, and oligosaccharides. The blood of SLE patients contains an increased amount of some specific miRNAs. This study aimed to analyze a possible hydrolysis of eight microRNAs found in the blood of SLE patients with high frequency by blood antibodies-abzymes.