Open Access<p>Activity Disease in SLE Patients Affected IFN-γ in the IGRA Results</p>
Author(s) -
Winni Maharani,
Dwi Febni Ratnaningsih,
Fitria Utami,
Fajar Awalia Yulianto,
Anneke Dewina,
Laniyati Hamijoyo,
Nur Atik
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s258235
Subject(s) - medicine , immunology , disease , latent tuberculosis , tuberculosis , quantiferon , immune system , gastroenterology , mycobacterium tuberculosis , pathology
Highly active systemic lupus erythematosus (SLE) causes a high risk of tuberculosis (TB) infection in SLE patients in Indonesia, a country in which the disease, especially extrapulmonary TB, is endemic. Interferon (IFN)-γ releasing assay (IGRA) can detect latent or previous TB infection. This study sought to determine latent TB infection and levels of IFN-γ, a key player in various inflammation and autoimmune disease, in patients with SLE and relate findings to disease activity.