Open Access<p>Defective Neutrophil Function in Patients with Sepsis Is Mostly Restored by ex vivo Ascorbate Incubation</p>
Author(s) -
Kritsanawan Sae-khow,
Sasipha Tachaboon,
Helen L. Wright,
Steven W. Edwards,
Nattachai Srisawat,
Asada Leelahavanichkul,
Direkrit Chiewchengchol
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s252433
Subject(s) - ex vivo , incubation , sepsis , in vivo , immunology , medicine , chemistry , microbiology and biotechnology , biology , biochemistry , genetics
Neutrophil function is essential for effective defence against bacterial infections but is defective in patients with sepsis. Ascorbate or vitamin C, which is low in the plasma of patients with sepsis, is stored inside human neutrophils and is essential for their normal function.