Open Access<p>NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle Synergistically Enhance Proinflammatory Reactions Both In Vitro and In Vivo</p>
Author(s) -
Amir I. Tukhvatulin,
Alina S. Dzharullaeva,
Alina S. Erokhova,
Dmitry Scheblyakov,
Boris S. Naroditsky,
Alexander L. Gintsburg,
Denis Y. Logunov
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s245638
Subject(s) - nod1 , proinflammatory cytokine , pattern recognition receptor , biology , receptor , microbiology and biotechnology , innate immune system , nod2 , cytokine , c type lectin , stimulation , immunology , inflammation , biochemistry , endocrinology
Pathogens consist of a wide variety of evolutionarily conserved molecular structures that are recognized by pattern recognition receptors (PRRs) of innate immunity. Reasonably assuming that no single PRR is ever likely to be the sole trigger of the immune response during infection, a great deal remains unknown about collaborative mechanisms and consequential crosstalk effects between multiple PRRs belonging to different families. Here, we aimed to investigate inflammatory response to combined stimulation of cytosolic nucleotide-binding oligomerization domain (NOD) receptors: NOD1, NOD2 and membrane-bound C-type lectin receptors (CLRs): Mincle and Dectin-1 in comparison to individual stimulation both in vitro and in vivo.