Open Access<p>Impact of Low Interferon-γ and IL-10 Levels on TNF-α and IL-6 Production by PHA-Induced PBMCs in Type 2 Diabetes Mellitus</p>
Author(s) -
Rona Kartika,
Dyah Purnamasari,
Saraswati Pradipta,
Rahma Ayu Larasati
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s245064
Subject(s) - peripheral blood mononuclear cell , tumor necrosis factor alpha , immune system , medicine , endocrinology , immunology , type 2 diabetes mellitus , interleukin , cytokine , interleukin 6 , diabetes mellitus , biology , in vitro , biochemistry
In this study, we analyzed the production of interferon γ (IFN-γ) and interleukin 10 (IL-10) by peripheral blood mononuclear cells (PBMCs) in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the capacity of monocytes to produce tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) following IFN-γ stimulation and the associated role of IL-10 in TNF-α and IL-6 production.