Open Access<p>Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies</p>
Author(s) -
Renata Curciarello,
T Sobande,
Samantha Jones,
Paolo Giuffrida,
Antonio Di Sabatino,
Guillermo Horacio Docena,
Thomas T. MacDonald,
Klaartje Kok
Publication year - 2020
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s234710
Subject(s) - elafin , neutrophil elastase , elastase , monoclonal antibody , ulcerative colitis , proteases , immunology , antibody , intestinal mucosa , ex vivo , microbiology and biotechnology , medicine , chemistry , inflammation , biology , in vitro , biochemistry , pathology , enzyme , disease
Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive infiltrate of neutrophils into the mucosa and hence, increased proteolytic activity. Human neutrophil elastase (HNE) is a serine protease that has been reported to be increased in UC patients' intestinal mucosa. Based on our previous studies, we hypothesized that HNE might induce proteolytic degradation and loss of function of therapeutic monoclonal antibodies in IBD patients.