Open AccessMCT4 Promotes Hepatocellular Carcinoma Progression by Upregulating TRAPPC5 Gene
Author(s) -
Niu Zhai,
Faji Yang,
Hongguang Li,
Jianlu Wang,
Qingqiang Ni,
Chaoqun Ma,
Huaqiang Zhu,
Hong Chang,
Xu Zhou,
Jun Lu,
Hengjun Gao
Publication year - 2022
Publication title -
journal of hepatocellular carcinoma
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2253-5969
DOI - 10.2147/jhc.s352948
Subject(s) - cancer research , carcinogenesis , cell growth , biology , hepatocellular carcinoma , rna interference , western blot , gene knockdown , cell migration , cell , cell culture , microbiology and biotechnology , cancer , rna , gene , biochemistry , genetics
Monocarboxylate transporter 4 (MCT4) is an important component of cancer cell glycolytic metabolism. It has been confirmed that MCT4 is highly expressed in hepatocellular carcinoma (HCC) cells and tissues and is significantly associated with poor prognosis of HCC patients. However, research on its downstream molecules that affect HCC is still insufficient. The aim of current research was to investigate the MCT downstream molecule and its role of in HCC development.