Open AccessA Genetic Variant of PPP1CB Influences Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma in Han Chinese: A Pathway Based Analysis
Author(s) -
Haoming Mai,
Haisheng Xie,
Jie Hou,
Haitao Chen,
Bin Zhou,
Deke Jiang
Publication year - 2021
Publication title -
journal of hepatocellular carcinoma
Language(s) - English
Resource type - Journals
ISSN - 2253-5969
DOI - 10.2147/jhc.s321939
Subject(s) - hepatocellular carcinoma , genome wide association study , single nucleotide polymorphism , hepatitis b virus , snp , odds ratio , biology , kegg , allele , ctcf , cancer research , genetics , oncology , medicine , genotype , gene , virus , gene expression , transcriptome , enhancer
Activation of actin cytoskeleton remodeling is an important stage preceding cancer cell metastasis. Previous genome-wide association studies (GWAS) have identified multiple hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)-associated risk loci. However, limited sample size or strict significance threshold of GWAS may cause HBV-related HCC risk-associated genetic loci to be undetected. We aimed to investigate the performance of the SNP rs13025377 in PPP1CB in HCC.