Open AccessFine Mapping of the MHC Region Identifies Novel Variants Associated with HBV-Related Hepatocellular Carcinoma in Han Chinese
Author(s) -
Haoming Mai,
Jiaxuan Chen,
Haitao Chen,
Zhiwei Liu,
Guanlin Huang,
Jialin Wang,
Qianyi Xiao,
Weihua Ren,
Bin Zhou,
Jilun Hou,
Deke Jiang
Publication year - 2021
Publication title -
journal of hepatocellular carcinoma
Language(s) - English
Resource type - Journals
ISSN - 2253-5969
DOI - 10.2147/jhc.s321919
Subject(s) - hepatocellular carcinoma , single nucleotide polymorphism , linkage disequilibrium , hepatitis b virus , human leukocyte antigen , biology , genome wide association study , snp , genetic association , major histocompatibility complex , zygosity , hepatitis b , allele , genetics , immunology , gene , virus , antigen , genotype
Genome-wide association studies identified susceptibility loci in the major histocompatibility complex region for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). However, the causal variants underlying HBV-related HCC pathogenesis remain elusive.