Open AccessThe Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target
Author(s) -
Xiangqian Guan,
Yuyan Lu,
Heping Zhu,
Shuqi Yu,
Wenxiu Zhao,
Xiaoqin Chi,
Chengrong Xie,
Zhenyu Yin
Publication year - 2021
Publication title -
journal of hepatocellular carcinoma
Language(s) - English
Resource type - Journals
ISSN - 2253-5969
DOI - 10.2147/jhc.s303588
Subject(s) - neutrophil extracellular traps , metastasis , hepatocellular carcinoma , cancer research , in vivo , cancer , cancer cell , in vitro , medicine , biology , immunology , inflammation , biochemistry , microbiology and biotechnology
Emerging evidences have highlighted the roles of neutrophils, as the major host microenvironment component, in the development of hepatocellular carcinoma (HCC). Neutrophils extracellular traps (NETs) produced in the infection can strengthen the behavior of cancer metastasis. Here, we investigated the roles of NETs in HCC metastasis and further explore the underlying mechanism of how NETs interact with cancer.