Open AccessBlocking the CCL5–CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells
Author(s) -
Yuan Zhuang,
Xiaomei Zhao,
Binhang Yuan,
ZhaoChong Zeng,
Yixing Chen
Publication year - 2021
Publication title -
journal of hepatocellular carcinoma
Language(s) - English
Resource type - Journals
ISSN - 2253-5969
DOI - 10.2147/jhc.s300165
Subject(s) - ccl5 , macrophage polarization , tumor necrosis factor alpha , chemokine , cytokine , biology , microbiology and biotechnology , chemokine receptor , cancer research , m2 macrophage , chemistry , macrophage , immunology , inflammation , t cell , in vitro , il 2 receptor , biochemistry , immune system
The C-C chemokine ligand 5 (CCL5)-C-C chemokine receptor (CCR5) axis facilitates tumor progression via multiple mechanisms. Herein, we elucidated the effect of a CCR5 antagonist (maraviroc [MVC]; blocking the CCL5-CCR5 axis) on the phenotype of macrophages cocultured with irradiated hepatoma cells. In addition, we investigated whether modulation of macrophage polarization can alter tumor cell sensitivity to radiation.