Open AccessMeriandra dianthera Aqueous Extract and Its Fraction Prevents Blood Coagulation by Specifically Inhibiting the Intrinsic Coagulation Pathway: An in vitro Study
Author(s) -
Filmon Kiflezghi Kiflemariam,
Abiel Ghebrehiwet Tewelde,
Ali Mahmud Hamid,
Bilal Mussa Beshir,
Samrawit Negasi Solomon,
Tesfu Gonets Eman,
Daniel Mebrahtu Abraha,
Russom Kahsu,
John Issac,
Jeevan Jyoti Kaushik
Publication year - 2022
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 12
ISSN - 1179-1454
DOI - 10.2147/jep.s362258
Subject(s) - chemistry , coagulation , chromatography , clotting time , aqueous solution , decoction , in vitro , hemolysis , residue (chemistry) , membrane , pharmacology , biochemistry , medicine , traditional medicine , immunology , organic chemistry
Currently, cardiovascular disorders are the primary cause of mortality in the world and constitute a serious medical problem. Blood coagulation is an essential process to prevent excessive blood loss through injured blood vessels; however, abnormal blood clotting in the blood vessels can result in fatal cardiovascular disorders. This study investigated the in vitro anticoagulant activity of Meriandra dianthera crude extract and its fractions and their erythrocyte membrane stabilizing activity.