Open AccessThe Effects of Furosemide on Behavioral and Hormonal Parameters in Male and Female Mice Subjected to Immobilization and Cold-Water Stress
Author(s) -
Mohammed Al Za’abi,
Badreldin H. Ali,
Yousuf Al Suleimani,
Ibrahim AlZakwani,
Balqees Al-Fulaiti,
P Manoj,
Abderrahim Nemmar
Publication year - 2021
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
ISSN - 1179-1454
DOI - 10.2147/jep.s305770
Subject(s) - furosemide , hormone , stress (linguistics) , endocrinology , psychology , medicine , philosophy , linguistics
The diuretic agent furosemide (FUR, 25 and 50 mg/kg) has been shown in a single report to act as an anti-stressor agent in two models of acute stress in mice, viz. electric foot-shock stress and immobilization (IMS). The present work aimed to investigate the possible anti-stressor action of FUR on two models of acute stress in mice, cold-water stress (CWS) and IMS, and tried to determine whether gender has any impact on the effect of FUR.