Open AccessEvaluation of Anti-Diarrheal Activity of 80% Methanol Extracts of Vernonia amygdalina Delile (Asteraceae) Leaves in Mice
Author(s) -
Biruk Mosisa Gudeta,
Getu Melesie Taye,
Teferra Abula,
Diriba Alemayehu Gadisa
Publication year - 2020
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
ISSN - 1179-1454
DOI - 10.2147/jep.s282669
Subject(s) - vernonia amygdalina , diarrhea , traditional medicine , loperamide , acute toxicity , medicine , castor oil , toxicity , biology , gastroenterology , biochemistry
Diarrhea is a cause of morbidity and mortality, especially in children. Patients with diarrhea have been suffering from limited treatment options due to poor drug tolerance, side effect, and multi-drug resistance to almost all the current drug treatments. Therefore, it is important to search for a new therapeutic medicine that can effectively prevent the disease and safe. Vernonia amygdalina is an indigenous medicinal plant used traditionally for the treatment of diarrhea in Ethiopia. The aim of this study was therefore to confirm the antidiarrheal activities of 80% methanol leaves extract using mice models.