Open Access<p><em>Zingiber officinale</em> Ethanolic Extract Attenuated Reserpine-Induced Depression-Like Condition and Associated Hippocampal Aberrations in Experimental Wistar Rats</p>
Author(s) -
Olanrewaju John Afees,
Joshua Owolabi,
Ifedamola Patience Awodein,
Joseph Igbo Enya,
Stephen Taiye Adelodun,
S Olatunji,
Oluseyi Fabiyi
Publication year - 2020
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 12
ISSN - 1179-1454
DOI - 10.2147/jep.s275260
Subject(s) - reserpine , glutathione reductase , glutathione , glutathione peroxidase , endocrinology , zingiber officinale , medicine , fluoxetine , hippocampus , chemistry , pharmacology , biology , catalase , oxidative stress , biochemistry , serotonin , traditional medicine , enzyme , receptor
Repeated and regimented treatment with reserpine causes depression-like condition characterized by persistent mood disorder, feelings of severe despondency and dejection, thus altering the hippocampal morphology. Our study compared a well-known antidepressant (fluoxetine), with the potential of Zingiber officinale to ameliorate reserpine-induced depression and the associated hippocampal cornu ammonis 1 (CA1) neuronal cell damage.