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There would be over 600 million people living with diabetes by 2040 as predicted by the World Health Organization. Diabetes is characterized by raised blood sugar and insulin resistance. Insulin regulates the influx of glucose into the cell by upregulating the glucose transporter type 4 (GLUT4) expression on the plasma membrane. Besides, PPAR-γ also controls the metabolism of glucose in adipose tissues. Curcuma mangga Val., denoted as C. mangga , is a native Indonesian medicinal plant that has many beneficial effects, including an antidiabetic potential.

journal of experimental pharmacology

&lt;p&gt;Hypoglycemic Activity of &lt;em&gt;Curcuma mangga&lt;/em&gt; Val. Extract via Modulation of GLUT4 and PPAR-γ mRNA Expression in 3T3-L1 Adipocytes&lt;/p&gt;