Open Access<p>Hypoglycemic Activity of <em>Curcuma mangga</em> Val. Extract via Modulation of GLUT4 and PPAR-γ mRNA Expression in 3T3-L1 Adipocytes</p>
Author(s) -
Dwiyati Pujimulyani,
Wisnu Adi Yulianto,
Astuti Setyowati,
Seila Arumwardana,
Hanna Sari Widya Kusuma,
Ika Adhani Sholihah,
Rizal Rizal,
Wahyu Widowati,
Ali Maruf
Publication year - 2020
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 12
ISSN - 1179-1454
DOI - 10.2147/jep.s267912
Subject(s) - glut4 , glucose transporter , 3t3 l1 , glucose uptake , endocrinology , rosiglitazone , medicine , adipogenesis , insulin resistance , insulin , carbohydrate metabolism , chemistry , adipocyte , peroxisome proliferator activated receptor , biology , adipose tissue , receptor
There would be over 600 million people living with diabetes by 2040 as predicted by the World Health Organization. Diabetes is characterized by raised blood sugar and insulin resistance. Insulin regulates the influx of glucose into the cell by upregulating the glucose transporter type 4 (GLUT4) expression on the plasma membrane. Besides, PPAR-γ also controls the metabolism of glucose in adipose tissues. Curcuma mangga Val., denoted as C. mangga , is a native Indonesian medicinal plant that has many beneficial effects, including an antidiabetic potential.