Open Access<p>The Potential Neuroprotective Role of Citicoline in Hepatic Encephalopathy</p>
Author(s) -
Omid Farshad,
Pedram Keshavarz,
Reza Heidari,
Mina Farahmandnejad,
Sara Azhdari,
Akram Jamshidzadeh
Publication year - 2020
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 12
ISSN - 1179-1454
DOI - 10.2147/jep.s261986
Subject(s) - citicoline , oxidative stress , neuroprotection , pharmacology , hepatic encephalopathy , antioxidant , hyperammonemia , medicine , neurotoxicity , encephalopathy , chemistry , endocrinology , biochemistry , toxicity , cirrhosis
Hepatic encephalopathy (HE) is described as impaired brain function induced by liver failure. Ammonia is the most suspected chemical involved in brain injury during HE. Although the precise mechanism of HE is not clear, several studies mentioned the role of oxidative stress in ammonia neurotoxicity. In animal models, the use of some compounds with antioxidant properties was reported to reduce the neurotoxic effects of ammonia, improve energy metabolism, and ameliorate the HE symptoms. Citicoline is a principal intermediate in the biosynthesis pathway of phosphatidylcholine that acts as neurovascular protection and repair effects. Various studies mentioned the neuroprotective and antioxidative effects of citicoline in the central nervous system. This study aims to investigate the potential protective effects of citicoline therapeutic in an animal model of HE.