Open Access<p>Protective Effect of <em>Croton macrostachyus</em> (Euphorbiaceae) Stem Bark on Cyclophosphamide-Induced Nephrotoxicity in Rats</p>
Author(s) -
Muluken Altaye Ayza,
Kumar Balasubramanian,
Dawit Zewdu Wondafrash,
Abera Hadgu Berhe
Publication year - 2020
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 12
ISSN - 1179-1454
DOI - 10.2147/jep.s260731
Subject(s) - nephrotoxicity , pharmacology , cyclophosphamide , toxicity , kidney , croton , chemistry , traditional medicine , medicine , chemotherapy
Cyclophosphamide is an alkylating antineoplastic agent and its major limitation is injury to normal tissue, leading to multiple organ toxicity, including kidney, heart, liver and reproductive toxicity. Croton macrostachyus (Euphorbiaceae) has been used in Ethiopian traditional medicine to manage renal diseases.