Open Access<p>Up-and-Coming Experimental Drug Options for Metastatic Colorectal Cancer</p>
Author(s) -
Sarah K Cimino,
Cathy Eng
Publication year - 2020
Publication title -
journal of experimental pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 12
ISSN - 1179-1454
DOI - 10.2147/jep.s259287
Subject(s) - colorectal cancer , medicine , cancer , disease , drug , oncology , intensive care medicine , pharmacology
Colorectal cancer is one of the top causes of cancer and cancer-related deaths worldwide. The prognosis of metastatic colorectal cancer is poor and treatment options are limited. Many patients will run out of treatment options before they become medically unfit for therapy. As such, there is a need to expand upon the current understanding of disease biology as well as drug resistance mechanisms in order to create new approaches for therapy. In this review article, we will discuss the mechanistic rationale and clinical data for new drugs and therapeutic combinations under development for metastatic colorectal cancer.