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Several studies have shown anti-inflammatory, anti-microbial, antifungal, and antioxidant effects from Citrus limon -peel essential oil (Cl-PEO). Cl-PEO can be developed as topical drugs for oral ulceration because of its potential active components. There have been no studies on the topical application of Cl-PEO inducing type IV hypersensitivity reaction.

<p><em>Citrus limon</em> Peel Essential Oil–Induced Type IV Hypersensitivity Reaction</p>