Open Access<p>Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats</p>
Author(s) -
Abbas Ali Vafaei,
Hossein Ali Safakhah,
Simin Jafari,
Azin Tavasoli,
Ali Rashidy-Pour,
Ali Ghanbari,
Seyed Ali Seyedinia,
Parnia Tarahomi
Publication year - 2020
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
ISSN - 1179-1454
DOI - 10.2147/jep.s250738
Subject(s) - hypoalgesia , neuropathic pain , cannabinoid receptor , cannabinoid , crocin , endocannabinoid system , pharmacology , receptor , medicine , endocrinology , chemistry , neuroscience , psychology , hyperalgesia , nociception , antagonist
Neuropathic pain involves injury or alteration of the normal sensory and modulatory nervous systems to produce a set of symptoms that are often difficult to treat. Previous study indicates that crocin has anti-inflammatory properties that may be mediated by the neurotransmitter system. In this study, we determine if there is an interaction between crocin and the cannabinoid system on chronic constriction injury (CCI)-induced neuropathic pain in male rats.