Open Access<p>Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics</p>
Author(s) -
Ehsan Mohammadi,
Tijs Louwies,
Claudio Pietra,
S. Robert Northrup,
Beverley GreenwoodVan Meerveld
Publication year - 2020
Publication title -
journal of experimental pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 12
ISSN - 1179-1454
DOI - 10.2147/jep.s249747
Subject(s) - ghrelin , visceral pain , medicine , nociception , irritable bowel syndrome , hyperalgesia , allodynia , endocrinology , inflammation , agonist , antagonist , receptor , pharmacology , somatic cell , receptor antagonist , chemistry , biochemistry , gene
The anti-nociceptive properties of ghrelin have been demonstrated in alleviating inflammatory and neuropathic pain. Whether a ghrelin receptor-mediated mechanism attenuates visceral and somatic pain in the absence of active inflammation remains to be explored. Here, we investigate the efficacy of peripherally restricted (ipamorelin) and a globally active (HM01) selective ghrelin receptor agonist in an experimental model of non-inflammatory visceral hypersensitivity and somatic mechanical allodynia.