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The severity of Plasmodium falciparum infections is associated with the ability of the infected red blood cells to cytoadhere to host vascular endothelial surfaces and to uninfected RBCs. Host blood group antigens and two serum proteins α 2 -macroglobulin (α 2 M) and IgM have been implicated in rosette formation in laboratory-adapted P. falciparum . However, there is only limited information about these phenotypes in clinical isolates.

journal of blood medicine

Influence of α2-Macroglobulin, Anti-Parasite IgM and ABO Blood Group on Rosetting in Plasmodium falciparum Clinical Isolates and Their Associations with Disease Severity in a Ghanaian Population