Open AccessInfluence of α2-Macroglobulin, Anti-Parasite IgM and ABO Blood Group on Rosetting in Plasmodium falciparum Clinical Isolates and Their Associations with Disease Severity in a Ghanaian Population
Author(s) -
Betty Bandoh,
Eric Kyei-Baafour,
Belinda Aculley,
William van der Puije,
Bernard Tornyigah,
Kwadwo Akyea-Mensah,
Lars Hviid,
Robert A. Ngala,
Margaret Frempong,
Michael F. Ofori
Publication year - 2022
Publication title -
journal of blood medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.676
H-Index - 18
ISSN - 1179-2736
DOI - 10.2147/jbm.s329177
Subject(s) - malaria , abo blood group system , plasmodium falciparum , parasite hosting , rosette (schizont appearance) , immunology , medicine , rosette formation , population , macroglobulin , group a , biology , virology , antibody , environmental health , computer science , world wide web
The severity of Plasmodium falciparum infections is associated with the ability of the infected red blood cells to cytoadhere to host vascular endothelial surfaces and to uninfected RBCs. Host blood group antigens and two serum proteins α 2 -macroglobulin (α 2 M) and IgM have been implicated in rosette formation in laboratory-adapted P. falciparum . However, there is only limited information about these phenotypes in clinical isolates.