Open AccessPrevalence of Factor V Leiden G1691A and Prothrombin G20210A Gene Mutation Among Pregnant Women: Experience from a Multi-Center Study in Nigeria
Author(s) -
Sarah JohnOlabode,
Kehinde Sharafadeen Okunade,
Ayorinde Babatunde James,
Gbenga Olorunfemi,
Obiefuna I Ajie,
Akinniyi Adediran Osuntoki,
Alani S Akanmu
Publication year - 2021
Publication title -
journal of blood medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.676
H-Index - 18
ISSN - 1179-2736
DOI - 10.2147/jbm.s308997
Subject(s) - medicine , factor v leiden , thrombophilia , prothrombin g20210a , population , preeclampsia , factor v , gene mutation , obstetrics , genetic testing , genotype , pregnancy , mutation , gynecology , genetics , venous thrombosis , thrombosis , gene , biology , environmental health
Inherited thrombophilia and venous thromboembolism (VTE) have been closely linked to adverse pregnancy outcomes such as preeclampsia/eclampsia contributing to increased maternal and perinatal morbidity and mortality. There is, however, little genetic data from Africa including Nigeria that explores the prevalence of common VTE genetic risk markers such as factor V Leiden mutation (FVL G1691A) and prothrombin gene mutation (F2 G20210A) among pregnant women in Nigeria.