Open AccessMurine Leukemia-Derived Extracellular Vesicles Elicit Antitumor Immune Response
Author(s) -
Alejandro Pando,
Loren D. Fast,
Patrycja M. Dubielecka,
Anna Chorzalska,
Sicheng Wen,
John L. Reagan
Publication year - 2021
Publication title -
journal of blood medicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.676
H-Index - 18
ISSN - 1179-2736
DOI - 10.2147/jbm.s308861
Subject(s) - extracellular vesicles , medicine , immune system , leukemia , immunology , extracellular , cancer research , microvesicles , microbiology and biotechnology , biology , biochemistry , microrna , gene
Extracellular vesicles (EVs) are heterogeneous lipid bilayer particles secreted by cells. EVs contain proteins, RNA, DNA and other cargo that can have immunomodulatory effects. Cancer-derived EVs have been described as having immunomodulating effects in vivo with immunosuppressive and pro-tumor growth capabilities. However, cancer-derived EVs have also been harnessed and utilized for anti-cancer potential.