Open AccessChlamydia pneumoniae-Induced IFN-Gamma Responses in Peripheral Blood Mononuclear Cells Increase Numbers of CD4+ but Not CD8+ T Effector Memory Cells
Author(s) -
Tamar A. SmithNorowitz,
Sarah Shidid,
Yitzchok M. Norowitz,
Stephan Kohlhoff
Publication year - 2021
Publication title -
journal of blood medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.676
H-Index - 18
ISSN - 1179-2736
DOI - 10.2147/jbm.s303275
Subject(s) - cd154 , cd8 , peripheral blood mononuclear cell , immunology , chlamydophila pneumoniae , cytotoxic t cell , interleukin 4 , interferon gamma , il 2 receptor , medicine , biology , cd40 , microbiology and biotechnology , cytokine , immune system , t cell , in vitro , antibody , chlamydiaceae , biochemistry
Chlamydia pneumoniae causes respiratory infection in adults and children. Previous studies in our laboratory identified significantly higher in vitro T lymphocyte responses to C. pneumoniae in children with asthma compared to healthy controls which may indicate the presence of T effector memory (TEM) lymphocytes.