Open AccessRevisiting Autoimmunity in Chronic Lymphocytic Leukemia: Prognostic Value of Positive Direct Antiglobulin Test in a Retrospective Study and Literature Review
Author(s) -
Shaimaa Ahmed,
Shimaa Abdallah Ahmed,
Mai Aly,
Eman M. Nagiub Abdelsalam,
Mahasen Saleh
Publication year - 2021
Publication title -
journal of blood medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.676
H-Index - 18
ISSN - 1179-2736
DOI - 10.2147/jbm.s296225
Subject(s) - medicine , chronic lymphocytic leukemia , chemoimmunotherapy , autoimmune hemolytic anemia , multivariate analysis , oncology , rituximab , gastroenterology , anemia , immunology , leukemia , lymphoma
A positive direct antiglobulin test (DAT) with or without autoimmune hemolytic anemia is a frequent finding in chronic lymphocytic leukemia (CLL). The heterogenic clinical course of CLL mainly depends on different pathogenetic mechanisms which appears in a form of variable biological and clinical features. These features allow stratification of patients into subsets with different outcomes.