Open AccessClinical Usefulness of Furosemide to Prevent Volume Overload Among Children and Young Adults with Transfusion-Dependent Thalassemia: A Randomized, Open-Label, Crossover Study
Author(s) -
Apichat Photia,
Chanchai Traivaree,
Chalinee Monsereenusorn,
Piyarat Simthamnimit,
Piya Rujkijyat
Publication year - 2020
Publication title -
journal of blood medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.676
H-Index - 18
ISSN - 1179-2736
DOI - 10.2147/jbm.s285647
Subject(s) - furosemide , medicine , crossover study , blood pressure , volume overload , blood transfusion , anesthesia , cardiology , heart failure , alternative medicine , pathology , placebo
Red blood cell transfusion is a key element of treatment among patients with transfusion-dependent thalassemia (TDT). Volume overload and HCC syndrome (hypertension, convulsion, and intracranial hemorrhage) are fatal complications related to transfusion. Furosemide has been widely used to prevent hypertension secondary to volume overload with unclear supportive evidence. This study aimed to evaluate the efficacy of furosemide to prevent volume overload among children and young adults diagnosed with TDT.